What Is Synevra UltraLift, and Who Is It For?
Short answer: Synevra Lift & Lock is a two-part skincare routine for women who want smoother-looking, hydrated skin after 50: the UltraLift peptide serum for the face and neck, plus a once-daily VitaLock Complex capsule. The serum pairs niacinamide with the Syn-Ake peptide and sodium hyaluronate, and the capsule adds vitamin C, biotin, zinc and B vitamins.
A quick note on how I wrote this: I have not used Synevra myself. This is an in-depth research review. I read both product labels line by line, checked the kit prices on the official website on October 10, 2026, and looked up the published research on the main ingredients.
The serum comes in a slim purple pump bottle that reads "Advanced Peptide Serum" and sums up its goals in three words: smooth, support and shine. The capsule bottle, VitaLock Complex, holds 60 capsules, two months at one a day. Together the brand calls them the Lift & Lock System: one step on the skin, one from within.
It's a natural fit for the woman who notices finer lines around her eyes and mouth, skin that feels drier than it used to, or a complexion that has lost a little of its glow. If that sounds familiar, you're in good company. The National Institute on Aging (NIA) explains that the loss of collagen and elastic fibers with age causes skin to develop wrinkles, and that hormonal changes such as menopause can make skin thinner and drier.
My skin and nail care after 50 guide covers the everyday habits that matter most at this stage. Synevra is built to sit on top of those habits as a simple morning-and-evening ritual.
Synevra at a glance
- Serum
- 0.5 oz / 15 ml pump
- Serum use
- 1 to 2 pumps, twice a day
- Capsule
- 60 per bottle, 1 a day
- Where
- Face and neck, not eye area
- Serum label
- Cruelty free
- Guarantee
- 60 days, money back
What's Inside the UltraLift Serum? The Label, Line by Line
Short answer: the UltraLift label lists ten ingredients: water, glycerin, niacinamide, dipeptide diaminobutyroyl benzylamide diacetate (the Syn-Ake peptide), zinc oxide, tocopheryl acetate (vitamin E), phenoxyethanol and ethylhexylglycerin (preservatives), sodium hyaluronate and guar gum. Niacinamide sits in third place, right after the water and glycerin base, and there is no added fragrance.
Cosmetic labels list ingredients from the largest amount to the smallest, so the order tells you a lot. Here is what each line on the UltraLift label is, and what the research has looked at:
Niacinamide 3rd on the label
Niacinamide is a form of vitamin B3, and it's one of the ingredients I'm always happy to see high on a serum label. Here it sits right after water and glycerin, the two ingredients that make up the base of the formula.
What the research looked at: a 2024 review in the journal Antioxidants describes niacinamide as one of the most widely used antioxidants in anti-aging skincare and notes that it has been studied in clinical research for fine lines and wrinkles, uneven pigmentation, rough texture and redness. The same review reports no irritation in tests at concentrations up to 5%, part of why it's such a common daily staple.
Syn-Ake peptide dipeptide diaminobutyroyl benzylamide diacetate
This long name is the heart of the "peptide" in Advanced Peptide Serum. Syn-Ake is a registered trademark of DSM Nutritional Products, and its maker, dsm-firmenich, describes it as a small synthetic peptide that helps reduce the appearance of wrinkles and laughter lines.
It's made in a laboratory. The peptide was designed to mimic the amino acid sequence of Waglerin-1, a peptide found in temple viper venom, and it contains no venom at all. Its aim is to help relax the look of expression lines, the ones that come from smiling, squinting and frowning.
What the research looked at: dsm-firmenich reports measuring smoothness and wrinkle depth on crow's feet after 28 days with a 4% Syn-Ake formula, and notes that the ingredient won the Swiss Technology Award in 2006, which fits the "Swiss Peptide Technology" wording on the Synevra label.
Glycerin and sodium hyaluronate the hydrators
Glycerin is the second ingredient on the label, and sodium hyaluronate is the salt form of hyaluronic acid. Both draw water into the top layer of the skin, which is what gives a serum that comfortable, plumped-up feel.
In its winter skin guide, the American Academy of Dermatology (AAD) recommends hyaluronic acid, noting it absorbs 1,000 times its weight in water, and lists glycerin among the ingredients that work well for dry skin. That's a reassuring pair to find in a serum for women whose skin is getting drier with age.
Zinc oxide and vitamin E tocopheryl acetate
Zinc oxide is a mineral used widely in skincare, and tocopheryl acetate is a stable form of vitamin E, a classic antioxidant in face serums. The label makes no sun protection (SPF) claim, so your daily sunscreen stays its own step, which I cover below.
The supporting cast preservatives and texture
Phenoxyethanol and ethylhexylglycerin keep the formula fresh after opening, and guar gum, from the guar bean, gives the serum its light, smooth texture. There's no added fragrance on the ingredient list, which I appreciate in anything I'd put on my face twice a day. The label also carries a "6M" symbol, meaning it's best used within six months of opening.
What's in the VitaLock Complex Capsule?
Short answer: each VitaLock capsule lists vitamin C 78.5 mg, niacin 15 mg, vitamin B6 0.8 mg, biotin 2,310 mcg, vitamin B5 7 mg, calcium 5.5 mg, zinc 6 mg and horsetail extract 12.5 mg. You take one capsule a day with a glass of water, and each bottle holds 60 capsules.
| Ingredient | Per capsule | Daily Value |
|---|---|---|
| Vitamin C (ascorbic acid) | 78.5 mg | 87% |
| Vitamin B3 (niacin) | 15 mg | 94% |
| Vitamin B6 (pyridoxine hydrochloride) | 0.8 mg | 47% |
| Biotin | 2,310 mcg | 7,700% |
| Vitamin B5 (d-calcium pantothenate) | 7 mg | 140% |
| Calcium (dicalcium phosphate) | 5.5 mg | 0.5% |
| Zinc (zinc oxide) | 6 mg | 54.5% |
| Horsetail (Equisetum arvense) extract | 12.5 mg | Not established |
The two lines I'd point out first are vitamin C and biotin. The AAD explains that vitamin C works as an antioxidant and supports collagen formation, and that biotin is said to improve skin health and promote hair and nail growth. Zinc and the B vitamins round out a classic beauty-from-within lineup, and horsetail is a traditional botanical often found in hair, skin and nail formulas.
The AAD also notes that a well-balanced diet is the best way to get the vitamins your skin needs, so I see VitaLock as a convenient daily top-up that keeps those nutrients in one easy capsule. The other ingredients are microcrystalline cellulose, a gelatin capsule, silicon dioxide, magnesium stearate and titanium dioxide, and the label says it's made in an FDA-registered facility.
How Does Synevra Work?
Short answer: Synevra works on two fronts. On the skin, niacinamide and the Syn-Ake peptide help smooth the look of fine and expression lines, while glycerin and sodium hyaluronate hold water in the surface for a hydrated, plumper look. From within, VitaLock adds vitamin C, biotin, zinc and B vitamins as a simple daily habit.
Smooth
Syn-Ake and niacinamide, for the look of fine lines and expression lines.
Hydrate
Glycerin and sodium hyaluronate, two humectants that draw water into the skin's surface.
Support from within
VitaLock's vitamin C, biotin, zinc and B vitamins in one daily capsule.
How Do You Use Synevra?
The serum label is simple: shake well, then massage one or two pumps onto clean skin on your face and neck, morning and evening, until it's fully absorbed. Keep it away from the eye area, and if it gets into your eyes, rinse them well with water.
For VitaLock, the label suggests one capsule a day with an 8-ounce glass of water. Keep the bottle away from heat, light and humidity, and stay within the recommended amount.
Start with a patch test
Any new skincare product is worth testing first. The AAD recommends applying it to a quarter-sized spot, such as the underside of your arm or the bend of your elbow, twice a day for seven to 10 days. If there's no redness, itching or swelling, you're ready to use it on your face and neck.
A simple daily skin routine with Synevra
Sunscreen is the habit with the strongest evidence behind it. The NIA notes that UV damage adds up over time and leads to wrinkles and premature skin aging, and the AAD recommends a broad-spectrum, water-resistant sunscreen with SPF 30 or higher every day on skin not covered by clothing. This is how I'd build the day around Synevra:
- Morning: gentle cleanse, one or two pumps of UltraLift on face and neck, then moisturizer if you like and sunscreen last.
- With breakfast water: one VitaLock capsule and a full 8-ounce glass of water.
- Evening: cleanse again and apply UltraLift before bed.
- Every week: a quick look in good light. Fine lines change slowly, so judge the routine over several weeks.
Synevra Pros and Cons
What I like
- Niacinamide sits third on the serum label, right after water and glycerin.
- Syn-Ake, a synthetic peptide made to help smooth the look of expression lines.
- Glycerin and sodium hyaluronate, two hydrators the AAD recommends for dry skin.
- No added fragrance on the ingredient list, and cruelty free per the label.
- A once-daily capsule with vitamin C, biotin, zinc and B vitamins, every amount printed.
- A routine that takes a minute, morning and evening.
- 60-day money-back guarantee and free US shipping on the Advanced and Ultimate kits.
Worth knowing before you buy
- Like most cosmetics, the serum lists its ingredients in order rather than by percentage, and niacinamide comes third, right after the water and glycerin base.
- The Syn-Ake research comes mainly from its maker, while niacinamide and the humectants beside it are among the best-studied ingredients in skincare.
- Kits start at two serums and sit in the premium range, and the Ultimate kit brings each serum down to $59 with free US shipping.
Who Should (and Shouldn’t) Use Synevra?
Short answer: Synevra suits women over 50 who want a simple routine for smoother, hydrated-looking skin, inside and out. Do a patch test first and keep the serum away from your eyes. Check with your doctor before taking VitaLock if you are pregnant or nursing, have a medical condition or take medication, and mention its biotin before any blood test.
A good fit if you
- Notice finer lines around your eyes and mouth, or skin that feels drier than it used to.
- Want one serum for the face and neck instead of a shelf of products.
- Like the idea of caring for your skin from the outside and the inside.
- Prefer labels that show every ingredient.
- Already wear sunscreen and want a gentle extra step on top.
Check first if you
- Have sensitive or reactive skin. Patch test first, and if irritation or a rash appears, stop and call your doctor, as the label advises.
- Have a blood test coming up. The AAD notes that biotin can affect some blood test results, and the FDA has reported falsely low troponin results (a heart test) caused by biotin. Tell your doctor and the lab that you take it.
- Are pregnant or nursing, under 18 or living with a medical condition. The VitaLock label asks you to talk to a physician first.
- Take medication. The AAD advises checking with your doctor before starting any supplement.
- Avoid gelatin. The VitaLock capsule shell is made of gelatin, so vegetarians may prefer to use the serum on its own.
For most healthy women over 50 who want an easy, label-transparent skin routine, Synevra is a pleasant ritual to add to the morning and evening. If your nails are on your mind too, my KeraFirm review looks at a formula made for nail care.
Is Synevra Legit?
Yes. Both products carry complete labels that name the distributor, Phyo Thrive Labs in Largo, Florida, along with a support email. The UltraLift serum is a cosmetic for external use and VitaLock Complex is a dietary supplement made in an FDA-registered facility. Buying from the official website, with its three clearly priced kits and 60-day money-back guarantee, is the simple way to get the genuine products and the current offer.
How I Scored Synevra
I score every product on the same seven criteria, explained on my about page. Here is how Synevra came out:
| Criterion | Score | Why |
|---|---|---|
| What it promises | 4.0 | A clear look-and-feel promise, smoother, hydrated and radiant-looking skin, kept to support language on both labels. |
| Ease of use | 4.5 | One or two pumps morning and evening, plus one capsule a day with water. Nothing to mix or measure. |
| How it's made and what it publishes | 4.5 | A full ingredient list on the serum and a complete Supplement Facts panel on the capsule, with the distributor named on both. |
| Evidence and research support | 4.0 | Niacinamide and the humectants are well studied in skincare, and the Syn-Ake peptide comes with its maker's own testing. |
| Price for what it is | 4.0 | A premium-range two-product routine that earns its price in the Ultimate kit: $59 a serum and $29 a VitaLock bottle, with free US shipping. |
| Checkout | 5.0 | Secure checkout on the official website, three clearly priced kits and a one-time payment with no subscription. |
| Guarantee | 5.0 | A 60-day money-back guarantee on every order. |
| Final score | 4.3 / 5 | A thoughtful two-step skin routine with fully printed labels and a 60-day guarantee. |
Technical note: this is an in-depth research review. The score is based on the two labels, the published research and the official offer as of October 10, 2026.
How Much Does Synevra Cost?
These are the prices on the official Synevra order page on October 10, 2026, in US dollars. The Serum and VitaLock columns show the price of each bottle. Every kit is a one-time payment, with no subscription, and the Advanced and Ultimate kits include two digital e-books, The Radiant Skin Rituals Guide and The Confidence Blueprint.
| Kit | Serum | VitaLock | Total | Shipping |
|---|---|---|---|---|
| Starter 2 UltraLift serums | $79 | Not included | $158 | $9.95 |
| Advanced 2 serums + 1 VitaLock + 2 e-books | $69 | $49 | $187 | Free (US) |
| Ultimate Best value 4 serums + 2 VitaLock + 2 e-books | $59 | $29 | $294 | Free (US) |
The Ultimate kit is the one I'd look at first. It brings each serum down to $59 and each VitaLock bottle to $29, ships free in the US, and its two VitaLock bottles cover 120 days at one capsule a day. Shipping to Canada, the UK, Ireland, Australia and New Zealand is $19.95.
Prices can change, so the official website always shows the current offer.
Go to Official Synevra Website
Does Synevra Have a Money-Back Guarantee?
Yes. Every Synevra order from the official website is backed by a 60-day money-back guarantee. If the routine isn't right for you, the company refunds your purchase. That's two full months of morning and evening use to see how your skin responds, so you can try it with real peace of mind.
Synevra FAQ
Is Synevra legit?
Yes. Synevra is a real two-part product with complete labels. The UltraLift serum lists all ten of its ingredients, VitaLock Complex has a full Supplement Facts panel and is made in an FDA-registered facility, and both labels name the distributor, Phyo Thrive Labs in Largo, Florida. Every order from the official website comes with a 60-day money-back guarantee.
Does Synevra contain snake venom?
No. The serum contains Syn-Ake, a small synthetic peptide made in a laboratory. Its maker, dsm-firmenich, designed it to mimic the amino acid sequence of Waglerin-1, a peptide found in temple viper venom, to help relax the look of expression lines. There is no venom of any kind in the formula.
Does the UltraLift serum contain vitamin C?
Not according to the serum label, which lists water, glycerin, niacinamide, the Syn-Ake peptide, zinc oxide, vitamin E (tocopheryl acetate), two preservatives, sodium hyaluronate and guar gum. The vitamin C in the Synevra system is in the VitaLock Complex capsule, at 78.5 mg per capsule.
Does Synevra work, and what can I expect?
Synevra is designed to help smooth the look of fine lines and support hydrated, radiant-looking skin. Niacinamide has been studied in clinical research for the look of fine lines and uneven tone, and the Syn-Ake peptide was tested by its maker on crow's feet over 28 days. Results vary from person to person, so give it several weeks of twice-daily use with sunscreen every morning. The 60-day guarantee covers that whole window.
Is Synevra safe? Does it have side effects?
The serum uses ingredients that are common in skincare, but any new product can irritate, so do a patch test first, keep it away from the eye area and stop if you notice redness or a rash. The VitaLock capsule has 2,310 mcg of biotin, which can affect some blood tests, so mention it before lab work. If you are pregnant or nursing, under 18, have a medical condition or take medication, ask your doctor first.
How do I use the UltraLift serum and VitaLock?
Shake the serum, then massage one or two pumps onto clean skin on your face and neck, morning and evening, until it is fully absorbed, keeping it away from the eye area. Take one VitaLock capsule a day with an 8-ounce glass of water. In the morning, finish with a broad-spectrum sunscreen.
Can I use Synevra with my other skincare products?
The serum label doesn't name any product to avoid, and in a routine it goes on clean skin before moisturizer and sunscreen. Introduce it on its own first, after a patch test, so you can tell how your skin responds. If you use a prescription treatment from a dermatologist, ask them how to fit the serum into that routine.
Does Synevra ship outside the US?
Yes. Synevra ships to the United States, Canada, the United Kingdom, Ireland, Australia and New Zealand. Orders leave within 24 to 48 hours with tracking by email. Delivery takes about 5 to 8 business days in the continental US, while international orders cost $19.95 to ship and arrive in about 12 to 20 business days.
How much does Synevra cost?
On October 10, 2026, the official website listed the Starter kit (2 serums) at $158 plus $9.95 US shipping, the Advanced kit (2 serums, 1 VitaLock and 2 e-books) at $187 and the Ultimate kit (4 serums, 2 VitaLock and 2 e-books) at $294, both with free US shipping. It is a one-time payment, with no subscription.
Is there a money-back guarantee?
Yes. Every Synevra order from the official website is backed by a 60-day money-back guarantee. If it isn't right for you, the company refunds your purchase, so you can try the routine with real peace of mind.
About the author: Diane Foster
Founder & writer, Primaurea · Updated
I'm 54 and went through a rough menopause transition, and I started Primaurea to share what I learned along the way. I write from that experience and from independent research, and reading labels line by line is a big part of it. I'm not a doctor, a dermatologist or a licensed nutritionist, and nothing here is medical advice. Read my story.
How this review was made: this research review is based on the UltraLift serum label, the VitaLock Complex Supplement Facts panel, the official order page, the prices listed on October 10, 2026 and the public sources below. The score comes from my seven fixed criteria. Questions about this page? You can reach me through my contact page.
Sources: NIA, Skin Care and Aging; AAD, Supplements for Your Skin; AAD, Winter Skin Survival Kit; AAD, How to Test Skin Care Products; AAD, Sunscreen FAQs; FDA, Biotin Interference with Troponin Lab Tests; dsm-firmenich, SYN-AKE; Marques et al., 2024 (niacinamide review).
Affiliate disclosure: this page may contain affiliate links, always to the official websites of the products mentioned. If you buy through one of these links, you support my work at no additional cost to you. This never influences what I write or the score.
A Simple Two-Step Ritual for Skin After 50
Synevra pairs a niacinamide and Syn-Ake peptide serum for the face and neck with a once-daily VitaLock capsule, with every ingredient printed on the labels, made to support smoother, hydrated, radiant-looking skin.
Go to Official Synevra WebsiteEvery order is backed by a 60-day money-back guarantee.